By M.D. Fulton Roberts

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Not all samples of T>u exhibit the same degree of weakness, some being less reactive than others ; the degree of weakness, however, seems to be precisely inheritable. DM is rare but is important because without adequate tests the DM could be missed and the subject classed as d. This error could lead to the administration of DM blood to a d person with the result that the recipient might form anti-D. A very rare experience, which is less easy to explain is the formation of anti-D by some DM persons.

I t is customary also to refer to three antigens A, B and H, the last probably being present in all cells though most manifest in those of Group O and only a little less so in those of Group A 2 . Group O and Group A 2 cells may be agglutinated by certain antisera some of which are called anti-H (for they are neutralised by saliva from secretors) and the others, not so neutralised, are called anti-O. This account carefully evades any explicit statement about the relationship between the gene O and the antigen H .

A similar chromosome deletion has been reported from America in which the E locus was missing. These deletions support strongly the presumed order DCE ; and the evidence generally implies that the D site is not as close to C as C is to E. Recently evidence has arisen to suggest that another locus exists for which the alleles have been called F and f. The order is almost certainly DCEF. There is yet another antigen whose place in the system is not yet clear—it may THE Bh C OMPLEX 39 be part of a further pair of alleles, which have been called, temporarily, V and v ; V is common in negroes and rare in white persons.

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