By Vincent J. Cristofalo PhD

This quantity provides a transparent, concise review of the present kingdom of data in regards to the biology of getting older ñ serving as either a useful graduate-level textual content and a key reference for working towards execs. Over a dozen wonderful participants probe the most recent advancements in our wisdom of why humans age and the way the method works. those authoritative chapters aren't simply written for biologists ñ yet for gerontologists mostly. Marks the 10th anniversary of the yearly overview of Gerontology and Geriatrics.

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L. ), Handbook of the biology of aging (p. 721). New York: Van Nostrand Reinhold. Strehler, B. L. (1977). ). New York: Academic Press. Swim, H. , & Parker, R. F. (1957). Culture characteristics of human fibroblasts propagated serially. American Journal of Hygiene, 45, 20. Szilard, L. (1959). On the nature of the aging process. Proceedings of the National Academy of Sciences of the USA, 45, 30. Tice, R. , & Setlow, R. B. (1985). DNA repair and replication in aging organisms and cells. In C. E. Fench, & E.

Progeria: A model disease for the study of accelerated aging. In A. Woodhead, A. D. Blackett, & A. ), Molecular biology of aging (pp. 375-396). New York: Plenum Press. Burger, P. , & Vogel, S. 1973. The development of the pathologic changes of Alzheimer's disease and senile dementia in patients with Down's syndrome. American Journal of Pathology, 73, 457-468. GENETIC DISEASES OF PREMATURE AGING 39 Cleaver, J. E. 1982. Normal reconstruction of DNA supercoiling and chromatin structure in Cockayne syndrome cells during repair of damage from ultraviolet light.

These studies verified that HA content in young children and adolescents was low but with age there was an eleva- 34 W. T. 4. Urinary hyaluronic acid excretion by progeria and normal subjects versus age. A 10- to 20-fold elevation is seen in comparison with age-matched controls and a modest increase with normal aging is observed. Figure plotted from data presented in Zebrower et al. (1985a) and additional unpublished data on older apparently normal subjects. tion to 5-6%. Elevated excretion of urinary HA may be a normal characteristic or biomarker of aging that occurs at an accelerated rate in progeria and WS.

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