By André Bryskier
Annotation Antimicrobial brokers: Antibacterials and Antifungals is an important revision of an unique French reference released via Ellipses in 1999. bargains 1000's of antibiotics and antimicrobial compounds: in improvement, experimental, and in useProvides an intensive replace of the unique French variation released in 1999, plus severe new materialPresents entire insurance of chemistry and synthesis, type, constitution & ndash;activity relationships, mechanisms of motion and resistance, breakpoints, in vitro/in vivo actions, epidemiology, pharmacokinetics, metabolism, and hostile eventsFeatures over 1,200 illustrations, over 1,500 tables, and greater than 3,000 referencesPresents new, huge chapters overlaying helicobacter pylori and methicillin & ndash;resistant Staphylococcus aureus (MSRA). �Read more...
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Additional info for Antimicrobial agents : antibacterials and antifungals
A number of semisynthetic studies based on penicillin G culminated initially in the phenoxypenicillins and subsequently in the group M penicillins at the beginning of the 1960s. At the same time, research based on cephalosporin C culminated in the semisynthesis of the ﬁrst cephalosporins. At the end of 1957, researchers at Glaxo in the United Kingdom succeeded in producing 100 g of cephalosporin C, from which its structure was deﬁned and published in 1961. D. C. Hodgkin and E. N. Maslen conﬁrmed its crystallographic structure.
Antimalarial agents were progressively prepared, such as plasmoquine in 1928, mepacrine in 1933, and chloroquine in 1939. 5. Sulfonamides The studies by Ehrlich profoundly affected pharmacological research at the end of the 19th century and beginning of the 20th century. Research was focused on dye substances. Dyes of the sulfonamide type were synthesized in 1908 by P. Gelmo and in 1919 by M. Heidelberger and W. A. Jacobs. The credit for demonstrating the antibacterial activity of sulfamidochrysoidine in vivo in the treatment of experimental streptococcal septicemia, despite the fact that the substance was inactive in vitro, goes to Gerhard Domagk.
The enrichment of our society and the protection against the social risks associated with disease, as well as the technological progress that has accompanied this prosperity, have resulted in the advent of “high-tech” medicine and surgery, and with them the corollary of the emergence of another form of infectious pathology due to new predators that lie at the basis of the nosocomial or opportunistic infections. The introduction of a new antibacterial agent causes an imbalance in the bacterial ecosystem which, if uncontrolled, results in the emergence in the ﬁeld of infectious diseases caused by bacteria that until then had been considered laboratory curiosities or that only very rarely affected humans, such as Mycobacterium avium.