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Extra resources for Biological Activities of Steroids in Relation to Cancer. Proceedings of a Conference Sponsored by the Cancer Chemotherapy National Service Center, National Cancer Institute, National Institutes of Health, U. S. Department of Health, Education and Welfare

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26. Beyler, R. , and Sarett, L. Η. J. Am. Chem. Soc. 82, 178 ( 1 9 6 0 ) . Bloom, Β. , Bogart, V. , and Pinson, R. Chem. & Ind. (London) p. 1317 (1959). Bowers, A. J. Am. Chem. Soc. 8 1 , 4107 (1959). , Ibanez, L. C , and Ringold, H. J. / . Am. Chem. Soc. 81, 5991 (1959). , and Ringold, H. J. J. Am. Chem. Soc. 80, 4423 (1958). Diassi, P. , and Sabo, E . F. / . Am. Chem. Soc. 8 1 , in press (1960). Edwards, J. , Ringold, H. , and Djerassi, C. Troc. Chem. Soc. p. 87 (1959). , and Borman, A. Vitamins and Hormones 16, 303 ( 1 9 5 8 ) .

The antihistamine itself has no effect on bronchial smooth muscle; it serves only to block the effect of histamine. This relationship usually states that the dose of active drug necessary to cause maximum response increases in a linear fashion with the increasing doses of the antagonist. Although a quantitative relationship exists between the active drug and its antagonist, the relationships are not strictly linear, but rather are curvilinear. There are several possible explanations for the curvilinear result; one implies that more than one molecule of antagonist combines with the receptor and that this combination occurs in stages.

9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. 20. 21. 22. 23. 24. 25. 26. Beyler, R. , and Sarett, L. Η. J. Am. Chem. Soc. 82, 178 ( 1 9 6 0 ) . Bloom, Β. , Bogart, V. , and Pinson, R. Chem. & Ind. (London) p. 1317 (1959). Bowers, A. J. Am. Chem. Soc. 8 1 , 4107 (1959). , Ibanez, L. C , and Ringold, H. J. / . Am. Chem. Soc. 81, 5991 (1959). , and Ringold, H. J. J. Am. Chem. Soc. 80, 4423 (1958). Diassi, P. , and Sabo, E . F. / . Am. Chem. Soc. 8 1 , in press (1960). Edwards, J. , Ringold, H. , and Djerassi, C.

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