By Icon Health Publications
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Extra info for Carnitine - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References
In particular, the relative importance of hepatic lipogenesis versus plasma FA uptake by the liver in the increased apoBlipoprotein secretion observed in insulin resistant animal models and humans has not been studied. The experiments proposed in this project are directed at unanswered questions related to FA regulation of apoB-lipoprotein assembly and secretion, including: (1) the effects of plasma albumin-delivered FA on each of the steps in apoBlipoprotein assembly and the expression of genes involved in maintaining hepatic lipid homeostasis; (2) the effects TG-rich remnant-like particle-delivered FA on apoBlipoprotein assembly and gene expression; and (3) the relative importance of insulin resistance/hyperinsulinemia versus increased plasma FA availability in the reaulation of apoB-lipoprotein assemblv and secretion.
Louis, Mo 63130 Timing: Fiscal Year 2001 Summary: Pediatric cardiomyopathy (CM) is a common cause of death and morbidity. Although multiple etiologies are known, until recently, the majority of cases were termed "idiopathic". Now, it is recognized that CM is familial in 20-50% of adult patients. In dominantly-inherited hypertrophic CM (HCM), single gene defects have been defined. Delineation of genetic causes of pediatric dilated CM, however, is virtually limited to those genes associated with muscular dystrophies.
Contributes to the transition between stable remodeling and CHF and, iii. Whether a metabolic intervention can attenuate the remodeling response and the transition from stable remodeling to CHF. ; Professor and Head; Neurology; Washington University Lindell and Skinker Blvd St. Louis, Mo 63130 Timing: Fiscal Year 2003; Project Start 01-MAY-1997; Project End 30-APR-2008 Summary: The Neurologic AIDS Research Consortium (NARC) will maintain an effective collaborative clinical study group dedicated to the study of HIV-associated neurologic disease.